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L., Hannappel, E., Sosne, G., & Kleinman, H
Importantly, recent studies aimed at blocking the metaorganismal TMAO pathway through multiple approaches have confirmed the inhibition of diet-dependent atherosclerosis in animal models, either by targeting the initial microbial formation of TMA from choline through use of a nonlethal small-molecule inhibitor (19), or by targeting the second step in the pathway, the major host gene responsible for converting microbe-generated TMA into TMAO, flavin monooxygenase 3 (20, 21)
Acknowledgments We thank Kristin Marie Bivens (Institute of Social and Preventive Medicine ISPM) for her editorial assistance
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PMID 23875108
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